AN UNBIASED VIEW OF LDN-27219 DRUG MECHANISM OF ACTION

A person significantly appealing compound is LDN-27219. When most tTG inhibitors are intended to bind for the protein crosslinking active web page, LDN-27219 as a substitute binds for the nucleotide binding pocket of your enzyme even though it really is in its shut-state conformation, and stabilizes that conformation to circumvent crosslinking acti